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兴贝抗咳颗粒通过调节酶/PAR2/TRPV1通路来改善后感染性咳的几内亚猪的咳过敏性

Yun Li¹, Ruiheng Zhao¹, Mengyuan Zhang²

¹Graduate School of Beijing University of Chinese Medicine, Beijing, 100-029, China; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100-029, China.

Journal of ethnopharmacology

|September 30, 2023

概括

兴贝抗咳颗粒 (XB) 通过减少咳频率和炎症,有效治疗感染后咳 (PIC). 它的机制涉及抑制巨细胞脱粒和神经性炎症,同时恢复呼吸道细菌平衡.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

兴北抗咳颗粒 (XB) 是一种中国传统药物,用于治疗感染后咳 (PIC).
它的治疗效果和机制尚不清楚.
这项研究研究了XB对PIC的药理基础.

研究的目的:

探索XB对感染后咳 (PIC) 的影响和机制.
为XB在治疗PIC的临床使用提供科学依据.

主要方法:

在几内亚猪中使用香烟烟雾和LPS诱导后感染性咳 (PIC).
评估了XB对咳频率,肺炎,炎症调解剂,巨细胞降粒物质和神经的影响.
测量了TRPV1,PAR2和PKC的蛋白质和mRNA表达.
使用16S rRNA测序分析了呼吸道细菌微生物群.

主要成果:

根据剂量,XB治疗减少了咳频率和肺炎.
在XB下降了炎症调解剂,巨细胞降粒物质 (酸酶,β-Hex) 和下调TRPV1,PAR2和p-PKC表达.
XB改善了神经 (SP,CGRP,NKA,NGF) 和调节的呼吸道细菌微生物群的水平.

结论:

在PIC中,XB可以缓解咳过敏和炎症.
机制包括抑制酸酶/PAR2/PKC/TRPV1通路和巨细胞降粒.
此外,XB还能恢复呼吸道细菌微生物群的稳态,支持其用于PIC.

关键词:

神经性炎症是一种神经性炎症.后感染性咳后感染性咳呼吸系统的细菌微生物群.在 TRPV1 中.兴北抗组织颗粒

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