腹腔大动脉动脉瘤患者的区域和全球大动脉脉冲波速
Marcus Lindenberger1, Magnus Ziegler2, Niclas Bjarnegård3
1Department of Cardiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
概括
腹腔大动脉动脉瘤 (AAA) 的男性腹腔大动脉中脉冲波速度 (PWV) 升高,表明大动脉硬度增加. 这种刚性也与AAA患者和对照组中中央脂肪度有关.
科学领域:
- 心血管研究研究心血管研究
- 医疗成像医学成像
- 血管生物学 血管生物学
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 涉及大动脉扩张,慢性炎症和弹性质降解,可能增加大动脉硬度和脉冲波速度 (PWV).
- 对AAA对大动脉硬性的特定区域影响,特别是在腹部大动脉中,仍然不清楚.
研究的目的:
- 评估AAA患者的全球和区域大动脉PWV.
- 为了在AAA患者和对照者之间比较腹部和胸部下降大动脉中的PWV.
主要方法:
- 一项实验性研究涉及25名AAA (>30毫米) 的男性患者和27名匹配的对照.
- 测量PWV使用平面化度计 (carotid-femoral PWV,cfPWV) 和4D流MRI进行区域评估.
- 还记录了血压和人类测量测量.
主要成果:
- 全球PWV在AAA组明显高于通过MRI和cfPWV的对照组 (p = .007).
- 区域PWV在AAA患者的腹部大动脉中较大 (p = .022) 但在胸部下降大动脉中相似 (p = .59).
- 在AAA患者和对照组中,PWV与中心脂肪的积极关联.
结论:
- 与对照人群相比,患有AAA的男性在腹部大动脉中表现出较高的PWV,但在胸部下降大动脉中没有.
- 大动脉硬与中心脂肪沉积有关.
- 需要进一步的研究来确定AAA和增加的区域大动脉硬性之间的因果关系.
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