高近视患者的神经血管合功能障碍:来自多模式磁共振成像分析的证据
Xiaopan Zhang1, Liang Liu2, Fan Yang3
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Key Laboratory of magnetic resonance and brain function, Zhengzhou 450052, China.
Journal of neuroradiology = Journal de neuroradiologie
|September 30, 2023
概括
高近视 (HM) 与大脑中神经血管合功能障碍有关. 神经元活动和血液流量的这些变化可能会影响HM患者的视觉调节机制.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 高近视 (HM) 是一个重要的公共卫生问题.
- 了解HM的潜在机制对于开发有效的干预措施至关重要.
研究的目的:
- 在高近视 (HM) 患者中调查神经血管合 (NVC) 功能障碍.
- 探索HM中NVC变化和临床指标之间的关系.
主要方法:
- 使用静止状态功能磁共振成像 (rs-fMRI) 来评估神经元活动 (DC,ReHo,ALFF,fALFF).
- 测量大脑血流 (CBF) 以表征大脑血液输液.
- 使用Pearson部分相关性分析将NVC模式与临床数据联系起来.
主要成果:
- 与对照人群相比,HM患者在37个大脑区域表现出显著的NVC变化.
- 主要受影响的区域包括前和后回转.
- 在下额回形和偏中叶部分的特定NVC变化 (ReHo-CBF,ALFF-CBF) 与视力敏度和折射误差相关.
结论:
- 在HM患者中,神经血管合在多个大脑区域异常变化.
- 这些发现表明,NVC功能障碍可能导致HM异常视觉调节.
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