在老鼠听觉皮层中,通过迷走神经刺激来频率特定调节振荡活动
Shinichi Kumagai1, Tomoyo Isoguchi Shiramatsu2, Akane Matsumura2
1Department of Neurosurgery, Jichi Medical University, Tochigi, Japan; Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan.
Brain stimulation
|September 30, 2023
概括
神经刺激 (VNS) 通过改变皮质路径来增强听觉处理. VNS通过胆固醇系统加强前通路,并通过诺亚上腺系统减少反通路.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 系统神经科学 系统神经科学
背景情况:
- 神经刺激 (VNS) 之前显示了感官皮层活动的改变,这表明前 (FF) 和反 (FB) 途径的转变.
- 皮层振荡可能表明FF-FB平衡,但VNS对这些振荡的神经调节作用尚不清楚.
研究的目的:
- 调查VNS如何调节听觉皮层振荡和潜在的神经调节机制.
- 为了确定VNS是否通过胆固醇和诺亚上腺系统影响FF和FB通路.
主要方法:
- 在大鼠中使用电皮质学来记录VNS和点击刺激期间的听觉皮质活动.
- 时间频率分析通过高频和低频功率估计了FF-FB路径调制.
- 对差异的分析评估了VNS效应和与胆固醇和腺抗剂的相互作用.
主要成果:
- VNS增加了听觉皮层唤起的潜能,马和β功率,同时降低了theta功率.
- 胆固醇抗剂阻断了VNS诱导的玛和β功率增加.
- 诺拉丁抗剂阻断了VNS诱导的甲基功率下降.
结论:
- 在听觉皮层中,VNS可能通过胆能作用增强FF通路,并通过听觉皮层的诺亚能作用减弱FF通路.
- 通过VNS进行的神经调制,为听觉处理和皮层增益控制提供了机械的见解.
相关概念视频
Hearing
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Auditory Pathway
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Equilibrium and Balance
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
Auditory Perception
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the cochlea, a...


