基于个体结果概况分析,根据密集降低血压的益处和危害进行平衡
Sandra M Shi1, Natalia Gouskova1, Chan Mi Park1
1Hebrew SeniorLife, Marcus Institute for Aging Research, Harvard Medical School, Boston, Mass.
The American journal of medicine
|September 30, 2023
概括
强化降低血压减少死亡和改善结果,特别是在脆弱的个体. 检查组合的益处-危害概况可以更清楚地了解治疗的有效性.
科学领域:
- 心脏病学 心脏病学
- 临床试验 临床试验
- 老年病的医生 老年病的医生
背景情况:
- 强化降低血压可以预防主要不良心血管事件 (MACE).
- 然而,密集治疗也可能导致严重不良事件 (SAE).
- 分析组合的益处-危害概况提供了比单独评估MACE和SAE更全面的评估.
研究的目的:
- 评估密集治疗与标准血压治疗的益处危害概况.
- 为了在不同的脆弱性子组中比较这些配置文件.
主要方法:
- 分析了来自9361名参与系统性血压干预试验 (SPRINT) 的数据.
- 强化 (静脉压<120 mm Hg) 与标准 (静脉压<140 mm Hg) 治疗组的比较.
- 定义一个4年的等级性结果概况,从活着没有事件到死者.
主要成果:
- 强化治疗组的死亡比例较低 (5%与6%相比).
- 强化治疗导致只有SAE的生存比例更高 (36%vs33%),MACE和SAE的生存比例更低 (6%vs5%).
- 在脆弱个体的密集治疗中,结果概况更为有利,但在非脆弱和脆弱前参与者的组之间是相似的.
结论:
- 结果分析是一个有用的方法,可以同时评估治疗的益处和危害.
- 强化降低血压显示出有利的益处-危害概况,特别是在脆弱的人群中.
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