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Updated: Jul 15, 2025

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

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乌比基因特异性蛋白酶11结构与工程基质模拟物复合,揭示了对杜比基因化选择性的分子特征

Sigrun K Maurer1, Matthias P Mayer1, Stephanie J Ward1

  • 1Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.

The Journal of biological chemistry
|September 30, 2023
PubMed
概括

研究人员阐明了由乌比基因特异蛋白酶 (USP) 进行的二维基因化选择性的分子基础,确定了USP11中的关键残留物,这些残留物歧视特定的乌比基因链,推动了抑制剂的开发.

关键词:
晶体结构 晶体结构囊蛋白酶酶的作用是什么没有二维基丁酶.脱维基化 (deubiquitination) 是一个过程.融合标签 融合标签 融合标签蛋白质酶蛋白质酶是一种蛋白质.选择性的选择性在任何地方都是无处不在的.基特异性蛋白质酶的使用.

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