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Updated: Jul 15, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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活跃性结肠炎患者的RNA寡核酸GUT-1的下注射:一个随机,双盲,安慰剂控制的2a期诱导试验

Raja Atreya1,2, Tanja Kühbacher3, Maximilian J Waldner1,2

  • 1Department of Medicine 1, University of Erlangen-Nürnberg, Erlangen, Germany.

Journal of Crohn's & colitis
|September 30, 2023
PubMed
概括

作为CHST15抑制剂的GUT-1显示出作为性结肠炎诱导疗法的前景. 一次250nM剂量改善了对常规治疗不耐药的患者的内镜,临床和组织学结局.

关键词:
在CHST15中,在GUT-1中使用.这是一种RNA寡核酸.性结肠炎是一种纤维化 纤维化在 submucosal 的注射.

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