在马德里居住的厄瓜多尔患者中,与HLA/KIR多态相关的冠状病毒-19疾病风险和保护因素
Antonio Balas1, Miguel Ángel Moreno-Hidalgo1, Fernando de la Calle-Prieto2
1Histocompatibility Unit, Centro de Transfusion de la Comunidad de Madrid, Madrid, Spain.
Human immunology
|September 30, 2023
概括
某些人类白细胞抗原 (HLA) 和杀伤细胞免疫球蛋白样受体 (KIR) 基因变异可能会影响厄瓜多尔人的COVID-19风险和严重程度. 具体来说,HLA-B*39和KIR2DS4可能会增加风险,而KIR3DL1可能会提供保护.
科学领域:
- 免疫遗传学 免疫遗传学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- COVID-19不成比例地影响了西班牙的移民人口.
- 遗传因素,包括人类白细胞抗原 (HLA) 基因型和杀手细胞免疫球蛋白样受体 (KIR) 基因,可能会影响个体对SARS-CoV-2的反应.
- 种族遗传变异可能会影响COVID-19易感性和疾病进展.
研究的目的:
- 在厄瓜多尔队伍中调查HLA和KIR基因型与COVID-19之间的关联.
- 为了确定潜在的遗传风险或COVID-19严重程度的保护因素.
主要方法:
- 在52名住院的厄瓜多尔COVID-19患者和87名对照群体中对HLA等位基因和KIR基因的表征.
- 患者和对照组之间的遗传频率的比较分析.
主要成果:
- 在COVID-19患者中增加HLA-B*39的频率和激活KIR2DS4 (具有HLA-C*04连接体).
- 在COVID-19患者中,KIR2DL1和KIR3DL1/Bw4受体/连接体组合的频率降低.
- 在严重的COVID-19病例中观察到HLA-A*24:02和HLA-DRB1*09:01等位基因的较低频率.
结论:
- 在厄瓜多尔人中,HLA-B*39等位基因可能是COVID-19的遗传风险因素.
- 激活受体KIR2DS4及其配体HLA-C*04可能会增加COVID-19的风险.
- 抑制受体KIR3DL1可能会在与HLA-Bw4.4相互作用时提供对严重COVID-19的保护.
- HLA-A*24:02和HLA-DRB1*09:01等位基因可以防止COVID-19的严重形式.
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