在模拟的Y位点给药中,奥马达环素与选择的肠道产品的兼容性
David A Butler1, Kelly Moolick1, Donavon McCray2
1Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.
Clinical therapeutics
|September 30, 2023
概括
奥马达环素 (一种四环环素抗生素) 与大多数静脉注射液体和药物相容,除了罗西米德. 这项研究评估了其在临床环境中安全同时使用的兼容性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 静脉注射药物兼容性 静脉注射药物兼容性
背景情况:
- 奥马达环素是一种广泛的四环环素抗生素,用于社区获得的细菌性肺炎和皮肤感染.
- 目前关于静脉注射奥马达环素兼容性的数据仅限于特定的溶液和专用线路.
- 了解与常见的静脉注射液和药物的兼容性对于安全的同时使用至关重要.
研究的目的:
- 评估奥马达环素与常用的静脉注射液体和药物的静脉注射兼容性.
- 通过模拟的Y-site给药来评估兼容性,以指导临床实践.
主要方法:
- 奥马达环素被制备为维护剂 (1 mg/mL) 和加载剂 (2 mg/mL) 的剂量.
- 模拟的Y位处方涉及将奥马达环素与水晶体和药物混合 (乳酸林格,硫酸,盐水与KCl,布米坦化,化,肝素,胰岛素).
- 兼容性被视觉评估,并使用Tyndall光束,显微镜和光谱仪在设定的时间点进行评估.
主要成果:
- 奥马达环素与乳酸林格溶液,硫酸,盐水与化,布米坦化,肝素和胰岛素的物理兼容性得到证明.
- 当高度的奥马达克林和富洛塞米德被结合时,观察到不相容性.
- 较低度的奥马达环素和富洛塞米德显示出兼容性.
结论:
- 奥马达环素在物理上与大多数经过测试的静脉注射液体和药物兼容,但不包括furosemide.
- 与兼容药物同时在Y部位服用奥马达环素被认为是安全的.
- 由于观察到的不相容性,应避免与富罗西米德同时服用奥马达环素.
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