神经生物标志物和体温对休马拉松跑的反应
M J Stacey1, T Leckie2, D Fitzpatrick3
1Academic Department of Military Medicine, Defence Medical Services, UK; Carnegie School of Sport, Leeds Beckett University, UK; Department of Surgery and Cancer, Imperial College London, UK.
Journal of science and medicine in sport
|September 30, 2023
概括
马拉松跑者在运动后显示S100β和神经元特异性酶 (NSE) 神经生物标志物增加. 然而,这些变化并没有表明中枢神经系统受到重大伤害,这表明其他因素影响神经生物标志物水平.
科学领域:
- 运动生理学 运动生理学
- 神经生物学 神经生物学 神经生物学
- 生物标志物研究的研究.
背景情况:
- 长时间的耐力运动,如马拉松,可以诱导生理压力.
- 了解神经生物标志物在应对运动热应激时的变化对于评估潜在的中枢神经系统 (CNS) 损伤至关重要.
- 以前的研究还没有完全阐明耐力赛期间高热度与外围神经生物标志物水平之间的关系.
研究的目的:
- 为了研究马拉松运动期间的运动-热应激和外周血液神经生物标志物水平之间的联系.
- 在马拉松跑者中分析神经元特异性酶 (NSE),S100结合蛋白B (S100β),状纤维酸蛋白 (GFAP) 和Ubiquitin carboxyl-terminal hydrolase异酶L1 (UCHL1) 的变化.
- 为了确定高温或运动持续时间是否会影响神经生物标志物度.
主要方法:
- 这是一项观察性研究,涉及到2022年布莱顿马拉松比赛的38名马拉松选手.
- 监测比赛中的核心温度 (Tc),以根据累积高温来分类热暴露 (高,中,低).
- 血液样本在基线收集,马拉松后立即收集,并在24小时后收集,以测量神经生物标志物 (NSE,S100β,GFAP,UCHL1),皮质醇,素和肌素.
主要成果:
- 在整个研究期间,状纤维酸蛋白 (GFAP) 和Ubiquitin carboxyl-terminal酶异酶L1 (UCHL1) 的水平保持稳定.
- 马拉松后和24小时后观察到S100结合蛋白B (S100β) 的显著增加.
- 神经元特异性酶 (NSE) 在马拉松后增加,较高水平与较长的跑步时间相关;然而,神经生物标志物反应与高温症没有显著差异.
- 皮质醇,平素和肌素对高热的反应不同,与神经生物标志物不同.
结论:
- 成功完成马拉松并没有与大量的神经元损伤的证据有关.
- 马拉松后S100β和NSE水平升高表明生理压力,但不一定是严重的中枢神经系统损伤.
- 进一步的研究应该探索超热症之外的因素,如运动持续时间和强度,以充分了解长期耐力运动中的神经生物标志物变化.
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