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与卵孔相关的中风相关的因素:SAFAS研究

T Pommier¹, A Lafont², R Didier¹

¹Cardiology Department, University Hospital, 14, rue Paul-Gaffarel, 21079 Dijon cedex, France; Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (EA 7460), Faculty of Health Sciences, université de Bourgogne, université de Bourgogne Franche-Comté, Dijon, France.

Revue neurologique

|September 30, 2023

概括

持久性卵孔 (PFO) 与密码性中风有关. 低水平的加勒-3和骨质保护素可能有助于识别患有PFO相关中风的患者,这表明了特定的临床和生物特征.

科学领域:

心脏病学心脏病学
神经学神经学
生物标志物研究生物标志物研究

背景情况:

持续性卵孔 (PFO) 是已知的加密性中风和中风复发的贡献者.
将PFO与缺血事件联系在一起的确切机制尚不清楚.
关于PFO相关中风生物标志物的诊断价值的数据有限.

研究的目的:

调查PFO相关中风和特定生物标志物之间的关联.
为了确定诊断PFO相关中风的潜在生物标志物.
描述PFO相关密码性中风患者的临床和生物表型.

主要方法:

对没有心房动病史的缺血性中风患者进行前性单中心研究.
系统的PFO查使用TRANSTHORACIC心电回声学与CLOSE试验标准.
多变量逻辑回归分析,以评估与PFO相关的中风与心脏纤维化和炎症的生物标志物 (银-3,GDF-15,ST-2,骨质保护素,NT-proBNP) 的关联.

主要成果:

10%的患者 (23/229) 患有与PFO相关的中风.
与PFO相关的中风患者比较年轻,高血压较低,小脑参与度较高.
低的加勒-3 (<9.5ng/mL) 和骨质保护素 (<1133pg/L) 水平独立地与PFO相关的中风相关 (分别为OR 3.4和5.0).

结论:

被归因于PFO的密码性中风患者表现出明显的临床和生物特征.
低血清水平的加勒-3和骨质保护素可以作为PFO相关中风的指标.
这些发现有助于识别可能受益于PFO评估的患者.

关键词:

生物标志物生物标志物专利对于形形的人.风险因素风险因素一次性中风,中风.

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