疫苗对黄金葡萄球菌 (Staphylococcus aureus) 殖民化的影响:系统性审查和元分析
Maria Tsirigotaki1, Emmanouil Galanakis1
1School of Medicine, University of Crete, Heraklion, Crete, Greece.
Vaccine
|September 30, 2023
概括
疫苗通常不会影响儿童长期携带金黄色葡萄球菌,尽管婴儿可能会经历暂时的变化. 流感疫苗与S. aureus的发病率降低有关,这需要进一步研究.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 越来越多的人对疫苗对微生物生态的非向影响感兴趣.
- 担心疫苗对黄金葡萄球菌携带的影响.
研究的目的:
- 系统地审查和综合疫苗对S. aureus携带影响的证据.
- 评估不同年龄组和疫苗类型的影响.
主要方法:
- 在主要数据库 (MEDLINE,Scopus,clinicaltrials.gov) 进行系统的文献搜索.
- 包括儿童和成年人的观察性和随机对照研究 (RCT).
- 使用随机效应模型进行聚合效应估计的元分析.
主要成果:
- 包括34项研究;大多数专注于肺炎球菌合疫苗 (PCV) 和流感疫苗.
- PCV对老年儿童的S. aureus携带没有长期影响,但在婴儿中短暂增加.
- 流感疫苗接种与S. aureus携带的减少有关.
结论:
- 肺炎球菌疫苗接种对S. aureus鼻携带儿童没有长期影响.
- 在PCV后的婴儿中观察到过渡性利基变化;流感疫苗接种降低了S. aureus携带.
- 其他疫苗的数据有限;持续的监测和研究至关重要.
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