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Updated: Jul 15, 2025

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis
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在R环中的RNA m5C修改作为Alt-NHEJ的关闭开关

Haibo Yang1,2, Emily M Lachtara1,3, Xiaojuan Ran1,3,4

  • 1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Nature communications
|September 30, 2023
PubMed
概括

DNA 损伤触发R-循环中的RNA m5C 修饰,影响DNA 修复路径的选择. 这一发现表明,向RNA m5C和DNA修复机制可能是一个新的癌症治疗策略.

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