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热失活的Bifidobacterium adolescentis通过帕内斯样细胞介导的干细胞激活来改善结肠衰老

Yadong Qi^1,2, Jiamin He^1,2, Yawen Zhang^1,2,3

¹Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Nature communications

|September 30, 2023

概括

热不活化的Bifidobacterium adolescentis通过促进肠干细胞 (ISC) 再生和增强肠道屏障完整性来缓解结肠衰老,可能是通过可溶性多糖.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
老年学是一门学科.

背景情况:

衰老导致肠干细胞 (ISC) 数量和功能下降,损害肠表皮完整性.
肠道微生物群在与年龄相关的ISC衰退中的作用在很大程度上是未知的.
了解微生物群对老化肠道的影响对于开发治疗策略至关重要.

研究的目的:

为了研究热不活化的Bifidobacterium adolescentis (B. adolescentis) 对结肠衰老的影响.
阐明B. adolescentis在衰老过程中影响肠干细胞 (ISC) 和结肠完整性的机制.

主要方法:

使用过早衰老的老鼠 (Terc-/-) 和自然衰老的老鼠模型.
在机械学研究中使用体外结肠状体模型.
分析了热不活化的B. adolescentis对结肠衰老和ISC再生的影响.

主要成果:

B. adolescentis显著减轻了与结肠衰老相关的变化.
通过Wnt/β-catenin信号传递增强肠道完整性和刺激Lgr5+ISC再生.
确定了帕内斯样细胞 (PLC) 和可溶性多糖体 (SPS) 作为B. adolescentis中介作用的关键参与者.

结论:

热不活化的B. adolescentis促进ISC再生,并保持肠道屏障功能在衰老中.
可溶性多糖体 (SPS) 被确定为B. adolescentis.的潜在活性成分.
B. adolescentis代表了一种有希望的基于微生物群的标,用于改善结肠衰老.

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