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Updated: Jul 15, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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一个CK2和SUMO依赖的,PMLNB参与的监管机制,控制BLM无处不在和G-quadruplex解决方案

Shichang Liu1, Erin Atkinson1,2, Adriana Paulucci-Holthauzen1

  • 1Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.

Nature communications
|September 30, 2023
PubMed
概括

这项研究确定了RNF111/Arkadia和ARKL1蛋白质,以及Promyelocytic白血病核体 (PML NBs),作为Boom综合征酶 (BLM) 蛋白质水平的关键调节者. 它们的协调作用控制核内的G-四重复结构.

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