代谢激素和脂肪组织动态的性别特异性差异是由中等低碳水化合物和性饮食引起的
Ilya Smolensky1,2, Kilian Zajac-Bakri3,4, Timothy Sasha Odermatt4
1Department of Community Health, University of Fribourg, 1700, Fribourg, Switzerland. ilia.smolenskii@unifr.ch.
Scientific reports
|September 30, 2023
概括
低碳水化合物饮食对雄性和雌性小鼠的影响不同. 虽然性饮食减少了男性的体重,但中度低碳水化合物饮食增加了女性的脂肪,这表明女性可能更容易受到不良影响.
科学领域:
- 营养和新陈代谢 营养和新陈代谢
- 内分泌学 在内分泌学.
- 肥胖问题研究研究
背景情况:
- 低碳水化合物饮食常见于肥胖和代谢障碍.
- 性饮食虽然有效,但很难维持,并携带诸如高脂血症等风险.
- 不那么限制性,以不和脂肪为基础的低碳水化合物饮食提供了一个潜在的替代方案.
研究的目的:
- 为了研究对低碳水化合物饮食的反应中的性别差异.
- 分析对代谢荷尔蒙和脂肪组织部分的影响.
- 在小鼠中比较基因和中等低碳水化合物饮食.
主要方法:
- 小鼠接受了基因或中等低碳水化合物饮食.
- 测量了体重,脂肪组织和关键的代谢激素 (胰岛素,胆固醇,FGF-21,瘦素,TNFɑ).
- 进行行为测试以评估饮食影响.
主要成果:
- 观察到显著的性别二重变异:基因饮食降低了体重和皮下脂肪,仅在男性中.
- 这两种饮食对两性之间荷尔蒙的变化都不同;性饮食影响胰岛素, ghrelin 和 FGF-21;适度饮食对男性的影响是素.
- 瘤消亡因子α (TNFɑ) 在两种饮食中的男性中暂时升高;没有观察到行为变化.
结论:
- 饮食干预对新陈代谢表现出复杂的,取决于性别的影响.
- 女性似乎更容易受到低碳水化合物饮食的不利代谢后果的影响.
- 研究结果强调,在低碳水化合物饮食策略中需要对性别进行具体考虑.
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