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Updated: Jul 15, 2025

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Published on: March 27, 2019

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通过改变人类胰腺内分泌细胞发育,PAX4功能丧失增加了糖尿病风险

Hwee Hui Lau1,2, Nicole A J Krentz3,4,5, Fernando Abaitua4

  • 1Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.

Nature communications
|September 30, 2023
PubMed
概括

转录因子PAX4影响2型糖尿病的风险. PAX4中的遗传变异会影响人类β细胞的功能和发育,影响胰岛素分泌,并可能导致糖尿病.

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