基于多个机器学习算法,预测2型糖尿病患者的三个月禁食血糖和糖化血红蛋白变化,基于多个机器学习算法
Xue Tao1, Min Jiang2, Yumeng Liu3
1Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China.
Scientific reports
|September 30, 2023
概括
这项研究开发了机器学习模型,以预测2型糖尿病患者 (T2DM) 的血糖变化. 这些模型准确地预测了未来的空腹血糖 (FBG) 和糖化血红蛋白 (HbA1c) 水平,以进行个性化治疗.
科学领域:
- 内分泌学和新陈代谢学
- 医疗保健中的人工智能
- 数据科学在医学中的数据科学
背景情况:
- 2型糖尿病 (T2DM) 的管理依赖于监测禁食血糖 (FBG) 和糖化血红蛋白 (HbA1c).
- 准确预测血糖波动对于有效的,个性化的T2DM治疗策略至关重要.
- 现有的预测方法可能缺乏为个性化患者护理所需的精度.
研究的目的:
- 开发和验证机器学习模型,用于预测T2DM患者的3个月血糖变化 (FBG和HbA1c).
- 确定影响血糖控制的关键临床和生活方式因素.
- 根据预测分析,实现个性化治疗调整.
主要方法:
- 追溯分析来自中国四川省 (2015-2020) 的真实世界T2DM患者数据.
- 应用16个机器学习算法,选择5个表现最好的模型.
- 组合学习和修改的随机森林技术被用于最终模型的构建.
- 使用的大型数据集:FBG模型的10万例和HbA1c模型的2169例.
主要成果:
- 集体学习和修改的随机森林模型显示出高预测性能.
- 曲线下的实现面积 (AUC) 值为FBG的0.819和HbA1c的0.970.
- 确定了关键预测因素:基线FBG和HbA1c,药物服药,随访结果,饮食,BMI和腰围.
- 模型显示出用于预测血糖控制指标的显著临床适用性.
结论:
- 机器学习模型可以准确地预测T2DM患者未来的FBG和HbA1c水平.
- 这些预测能力支持开发个性化治疗计划.
- FBG和HbA1c是相互依赖的预测指标,突出了它们在糖尿病管理中的联合重要性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Diabetes: Symptoms, Diagnosis, and Complications
573
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
573
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Pathophysiology of Diabetes
971
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
971
Diabetes: Management and Pharmacotherapy
302
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
302


