SARS-CoV-2 儿科住院病例的分类:三角形与欧米克朗变异
Stephanie S Montarroyos1, Beatriz F Ladd1, Marcos Mestre1
1Nicklaus Children's Hospital, Miami, Florida.
Hospital pediatrics
|September 30, 2023
概括
儿童的COVID-19住院治疗在三角洲变种期间比Omicron更严重. 在这两种变种期间,较年轻的儿童 (<5岁) 更有可能专门接受COVID-19的治疗.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- COVID-19 在儿科患者群体中带来了独特的挑战.
- 了解变种对儿科住院的特定影响对于公共卫生至关重要.
- 将录取分类为被认为是
研究的目的:
- 根据入院原因分类儿童COVID-19住院: "因为COVID-19"或"有COVID-19".
- 为了比较Delta和Omicron变种占主导地位的时期之间的疾病严重程度和患者年龄.
- 在住院儿童中分析变种类型,入院原因,疾病严重程度和年龄之间的关联.
主要方法:
- 对2021年7月至2022年2月因COVID-19住院的儿科患者 (≤18岁) 的回顾性研究.
- 根据住院时间,儿科重症监护室 (PICU) 住院时间和Remdesivir收据来评估疾病的严重程度.
- 统计分析包括奇平方测试和科克兰-曼特尔-汉泽尔测试.
主要成果:
- 分析了492例儿科住院病例;更多的病例发生在Omicron时期 (n=307).
- "COVID-19"的入院在三角洲变种期间更频繁 (P < .001).
- 在三角洲时期 (P < .001) 观察到更高的疾病严重程度 (PICU入院,雷梅西维尔使用,停留时间更长).
- 年龄较小的儿童 (<5岁) 在三角形 (OR 2.6) 和奥米克朗 (OR 5.7) 期间"因COVID-19"入院的几率更高.
结论:
- 与Omicron相比,儿童COVID-19住院患者在三角洲变种占主导地位期间表现出更大的疾病严重性.
- 尽管整体住院率较低,但三角洲变种与儿童更严重的疾病有关.
- 幼儿 (<5岁) 代表了不同变种浪潮中COVID-19初级入院的脆弱群体.
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