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患有注意力缺陷/多动症障碍的儿童的症状引导的多式神经图像融合模式及其潜在的"大脑结构-功能-认知-行为"病理途径

Yuan Feng^1,2, Dongmei Zhi³, Yu Zhu^1,2

¹Peking University Sixth Hospital/Institute of Mental Health, No.51, North Huayuan Road, Haidian District, Beijing, 100191, China.

European child & adolescent psychiatry

|September 30, 2023

概括

儿童注意力缺陷/多动障碍 (ADHD) 的结构性大脑差异影响执行功能和行为. 灰质体积和大脑活动异常与自我调节受损和多动性有关.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
医疗成像医学成像

背景情况:

注意缺陷/多动障碍 (ADHD) 涉及复杂的大脑-认知-行为路径.
了解这些途径需要整合结构和功能大脑数据.

研究的目的:

研究多式神经成像模式如何与ADHD的执行功能 (EF) 和行为有关.
探索大脑结构,功能和临床症状之间的关系.

主要方法:

在152名ADHD儿童和102名健康对照 (HC) 中利用多式神经成像 (灰质体积和fALFF).
采用了相关性和调解分析,使用总症状得分 (TO) 和执行功能指数.

主要成果:

在前额头-状-小脑电路中,ADHD在默认模式网络 (DMN) 和低频波动 (fALFF) 分数幅度中显示灰色物质体积 (GMV) 异常.
在ADHD中GMV通过metacognition指数影响TO;在HC中fALFF通过行为调节指数 (BRI) 调解TO.
在HC中的GMV影响了fALFF,调节了BRI和过敏冲动性.

结论:

在ADHD中DMN的结构异常可能会损害前额头-状-小脑功能.
这种障碍会影响执行功能,如抑制和情绪控制,导致过度活跃-冲动行为.

关键词:

更多关于 ADHD ADHD 的文章执行职能执行职能执行职能多模体MRI融合技术多模体MRI融合技术病理途径病理途径

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