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怀孕中的研究伦理:母胎两位数
Marlyse F Haward1, Michelle H Lucena1, Mamta Fuloria1
1Department of Pediatrics, Division of Neonatology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.
NeoReviews
|September 30, 2023
概括
临床研究历来排除了孕妇,限制了对她们护理的证据. 在试验中公平的纳入对于道德决策和尊重母亲和胎儿健康方面的自主性至关重要.
科学领域:
- 医学伦理 医学伦理
- 临床研究 临床研究
- 生殖健康 生殖健康
背景情况:
- 有限的临床证据存在于怀孕特异性疾病的疗法,由于历史研究排除.
- 对胎儿伤害的恐惧导致了侵蚀孕妇在医疗保健决策中的自主权的做法.
- 母胎健康研究中的伦理考虑需要平衡风险和收益.
研究的目的:
- 审查临床研究伦理学对孕妇的历史背景.
- 检查母胎二元期内关键的伦理概念.
- 以2019年冠状病毒病 (COVID-19) 流行病作为案例研究来分析伦理紧张局势.
主要方法:
- 临床研究伦理学的历史审查.
- 在怀孕的背景下分析道德原则 (正义,仁慈,非邪恶,自主).
- 涉及孕妇的COVID-19研究的案例研究分析.
主要成果:
- 过去的研究实践已经为怀孕的个人创造了显著的证据差距.
- 怀孕个体在研究中的自主原则往往与其他伦理考虑相矛盾.
- 随着COVID-19的流行,正在进行的关于将孕妇纳入临床试验的辩论得到了重视.
结论:
- 在临床试验中,需要从"常规排斥"转向"公平纳入"的模式转变.
- 确保公平的包容性维护道德原则,尊重孕妇的权利.
- 基于证据的孕妇护理需要她们公平地参与研究.
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