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Updated: Jul 15, 2025

Ex Vivo Perfusion of the Rodent Placenta

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

大麻的胎盘排放:一个ex vivo perfusion研究

Erez Berman¹, Natalia Erenburg¹, Ron Beloosesky²

¹Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel.

|October 1, 2023

概括

大麻 (CBD) 在胎盘组织中积累,减少胎儿暴露. 然而,这种胎盘封存并不能证实对孕妇的安全性,需要进一步研究胎儿神经发育风险.

科学领域:

药理学药理学是指药理学的学科.
产科产科产科产科产科
发育毒理学发展毒理学

背景情况:

由于缺乏安全数据,不建议在怀孕期间使用大麻 (CBD).
在患有的女性中,超过50%的怀孕是无意的,导致潜在的胎儿CBD暴露.
CBD的脂友性质表明可以通过胎盘转移.

研究的目的:

为了研究CBD的胎盘分布特征.
评估CBD对胎盘功能的短期影响.
为了估计母亲CBD给药后的胎儿暴露水平.

主要方法:

从接受剖腹产的健康妇女获得的人类胎盘的ex vivo输液.
在低 (250 ng/mL) 和高 (1000 ng/mL) 的治疗度中输注含有CBD的介质.
使用LC-MS/MS量化CBD度在母体和胎儿区以及胎盘组织中的量化.
使用定制基因面板阵列对胎盘基因表达的分析.

主要成果:

CBD被隔离在胎盘组织中,具有显著的样本间变异性 (中位数为5342 ng/g).
胎儿区的CBD度明显低 (五分之一) 于母体区的度 (中位数为59 ng/mL与280 ng/mL).
在CBD暴露后,没有观察到胎盘基因表达的显著变化.

结论:

胎盘充当CBD的储存库,可能会减缓其转移到胎儿.
减弱的胎盘移植并不等同于胎儿安全.
怀孕登记册和神经认知评估对于确定产前CBD暴露风险至关重要.

关键词:

抗发作药物抗发作药物胎儿的胎儿是一个胎儿.怀孕怀孕怀孕怀孕怀孕这种特异性是teratogenicity.

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