通过Omicron XBB.1.16继续逃避中和抗体反应
Julia N Faraone1, Panke Qu2, Yi-Min Zheng2
1Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.
Cell reports
|October 1, 2023
概括
奥米克朗XBB.1.16变种显示出显著的免疫逃避,类似于XBB.1.5,挑战COVID-19疫苗. 这凸显了持续监测变种和更新疫苗配方的必要性.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 演变,特别是像XBB这样的Omicron变种,对疫苗有效性构成挑战.
- 欧米克朗XBB系表现出大量的免疫逃避对抗mRNA疫苗接种和COVID-19感染的抗体.
- 有E180V和K478R突变的XBB.1.16变种正在全球出现,需要进行比较分析.
研究的目的:
- 为了比较SARS-CoV-2 XBB.1.16变种与XBB.1.5和早期变种的免疫逃生特性.
- 为了评估与XBB.1.5.5相关的XBB.1.16尖端蛋白的融合性.
- 强调持续监测病毒演变和疫苗更新的必要性.
主要方法:
- 使用两价疫苗和三剂疫苗接种卫生保健工作者的血清进行免疫逃避的比较分析.
- 在BA.4/5波期间康复的个体血清的评估.
- 评估与特定突变相关的尖端蛋白融合性.
主要成果:
- 在各种接种疫苗和康复的人类血清中,XBB.1.16表现出强烈的免疫逃避,与XBB.1.5相似.
- 与XBB.1.5.5相比,XBB.1.16尖端蛋白具有较低的融合性.
- XBB.1.16的减少融合性表型取决于E180V和K478R突变的存在.
结论:
- 变种XBB.1.16具有显著的免疫逃生威胁,需要保持警.
- 更新的mRNA疫苗配方可能需要解决新出现的XBB.1.16.6.等变种所带来的免疫逃避问题.
- 对SARS-CoV-2变种的持续监测对于公共卫生战略至关重要.
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