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在动脉瘤下关节出血之前使用抗血小板药物的患者中,血小板输血和再出血率
Martina Sebök1,2, Natalie Zaugg3, Emanuela Keller4,2
1Departments of1Neurosurgery and.
Neurosurgical focus
|October 1, 2023
概括
在患有动脉瘤下关节出血 (aSAH) 的患者中输血血栓细胞可以降低再出血的风险. 然而,这种干预似乎不会影响这些患者的长期临床结果.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 动脉瘤下关节出血 (aSAH) 携带重出血的重大风险,这往往是多因素的.
- 在aSAH患者中使用抗血小板治疗与增加的复出出血率和较差的结果有关.
- 血小板输血在减轻这些风险中的作用尚不清楚.
研究的目的:
- 调查血小板输血对aSAH患者复出出血率的影响,这些患者在出血之前服用抗血小板药物.
- 评估血小板输血对aSAH后6个月临床结果的影响.
- 在分析中考虑潜在的混因素.
主要方法:
- 从一个专门从事aSAH的第三级中心收集未来的数据.
- 患有aSAH和先前存在的抗血小板药物使用的患者被分为输血和非输血组.
- 采用多变量逻辑回归来分析血小板输血与再出血/临床结果之间的关联.
主要成果:
- 总共有157名患者被分析,其中87人接受了血小板输血.
- 与非输血组 (17.1%) 相比,血小板输血组的复出率较低 (6.9%).
- 在调整了混杂因素后,血小板输血与再次出血风险降低有关 (aOR 0.29).
- 血小板输血没有显示出与6个月的不良临床结果 (aOR 0.91) 有意义的关联.
结论:
- 在先前使用抗血小板剂的aSAH患者中,血小板输血独立地与再次出血率的降低有关.
- 没有观察到血小板输血对6个月后临床结果的显著影响.
- 需要进一步的大规模,随机的研究来证实这些发现,并阐明血小板输血的确切作用.
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