在患有精神分裂症的医疗补助受益人中,使用第一代和第二代长效注射抗精神病药物的种族差异
Jacqueline Pesa1, Zhiwen Liu1, Alex Z Fu2
1Janssen Scientific Affairs, LLC, Titusville, NJ, USA.
Schizophrenia research
|October 1, 2023
概括
黑人精神分裂症患者在10年内比白人患者更有可能接受第一代 (FG) 长效注射抗精神病药物 (LAI). 这表明在抗精神病治疗的开始和质量方面存在种族差异.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 对抗精神病药物处方的种族差异已经得到了充分的证据.
- 本研究研究了影响第一代 (FG) 和第二代 (SG) 长效注射抗精神病药物 (LAI) 之间的选择因素.
研究的目的:
- 评估与成年精神分裂症患者的FG与SG LAI利用相关的人口和临床因素.
- 为了确定在开始长效注射抗精神病药物时的种族差异.
主要方法:
- 对医疗补助申请数据 (2009-2018) 的回顾性队列分析.
- 纳入标准:精神分裂症的成年人,LAI索赔,已记录的种族 (黑人或白人) 和入学前12个月.
- 多变量逻辑回归分析了种族,人口统计,临床因素和FG与SG LAI启动之间的关联.
主要成果:
- 这项研究包括10,773名患者 (62%是黑人,38%是白人).
- 与白人患者 (38.9%) 相比,黑人患者的FG LAI利用率更高 (46.8%).
- 黑人患者开始FG LAI的可能性比白人患者高1.47倍 (OR: 1.47;95%CI: 1.34,1.62),即使在对照共变量后. 年龄较大,FG口服抗精神病药物使用,管理护理覆盖率和较高的并发症负担预测了FG LAI使用.
结论:
- 在过去的十年中,黑人医疗补助受益者患有精神分裂症的FG LAI比白人受益者更频繁.
- 研究结果表明,在精神分裂症的LAI启动中存在种族差异.
- 这些差异可能会影响不同种族群体接受的精神分裂症治疗的质量.
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