多发性硬化症患者:基于全国性队列研究的COVID-19相关疾病活动和住院情况
Mette Louise Andersen1, Floor Dijkstra Zegers1, Line Riis Jølving1
1Center for Clinical Epidemiology, Odense University Hospital, Kløvervænget 30, Entrance 216, 5000, Odense C, Denmark; Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern, Kløvervænget 30, Entrance 216, 5000, Odense C, Denmark.
Multiple sclerosis and related disorders
|October 1, 2023
概括
COVID-19没有增加多发性硬化症疾病的活动. 然而,患有多发性硬化症的患者在阳性测试后30天内面临更高的COVID-19住院风险,无论治疗方式如何.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19对多发性硬化症 (MS) 疾病活动和住院风险的影响尚不清楚.
- 这项研究调查了COVID-19感染和MS疾病活动代理,如皮质类固醇使用和神经病医院接触之间的关联.
- 它还检查了与其他自身免疫疾病患者和普通人群相比,MS患者的COVID-19住院治疗风险.
研究的目的:
- 为了确定COVID-19是否会在多发性硬化症患者中触发疾病活动.
- 在多发性硬化症患者中评估COVID-19入院的风险.
- 评估疾病修饰治疗对MS患者COVID-19住院风险的影响.
主要方法:
- 全国卫生登记处分析了2,222,946名COVID-19 PCR检测结果呈阳性的个体的数据.
- 疾病活动代理物 (皮质类固醇处方,神经病学入院) 在MS患者的COVID-19感染前和后进行了比较.
- 后勤回归模型估计了MS患者的住院几率比率相对于自身免疫疾病患者和一般人群,调整了混因素.
主要成果:
- COVID-19感染并没有显著改变皮质类固醇处方率 (aIRR 0.93) 或MS的神经病医院接触率 (aIRR 1.10).
- 多发性硬化症患者在感染后30天内患有COVID-19住院的风险显著增加 (aOR为3.21与其他自身免疫性疾病相比;aOR为5.34与普通人群相比).
- 使用疾病修饰治疗并没有增加COVID-19住院的风险 (aOR 0.94).
结论:
- 在多发性硬化症患者中,COVID-19感染似乎不会触发疾病活动.
- 多发性硬化症患者因COVID-19而面临住院的风险大幅增加.
- 改变疾病的治疗方法在多发性硬化症患者中不会增加COVID-19住院的风险.
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20COPD: Pathogenesis and Clinical Features
327
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
327
01:18Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
01:22Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K