用于治疗神经退行性疾病的天然产品
Donghan Cui1, Yajuan Chen2, Bengui Ye3
1Division of Abdominal Tumor Multimodality Treatment, Cancer Center and State Key Laboratory of Biotherapy, Sichuan University, West China Hospital, Chengdu 610041, China.
概括
天然产品在治疗神经退行性疾病 (如阿尔茨海默氏症和帕金森症) 中表现有前途,通过向关键分子通路来治疗这些疾病. 本综述探讨了它们的潜在治疗开发机制.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 神经退行性疾病,包括阿尔茨海默氏症 (AD) 和帕金森病 (PD),在全球普遍存在,其特点是神经元损失和蛋白质积累.
- 天然产品为神经疾病提供治疗潜力,有助于神经修复和改善功能.
- 新兴的研究将神经炎症和特定的信号通路 (例如NF-κB,MAPK,Nrf2/HO-1) 与AD和PD病变发生联系起来.
研究的目的:
- 审查天然产品在预防和治疗阿尔茨海默病 (AD) 和帕金森病 (PD) 的作用机制.
- 为自然产品在神经退行性疾病管理中的临床应用提供理论基础.
主要方法:
- 对2012年至2022年间发表的研究进行了全面的文献搜索.
- 搜索的数据库包括ScienceDirect,Springer,PubMed,谷歌学者等,使用关键词如"神经障碍"",天然产品"和"信号通路".
主要成果:
- 该综述总结了主要神经退行性疾病的病原性.
- 它强调了针对神经退行性疾病进行研究的天然产品的最新发现.
- 详细介绍了这些天然产品发挥作用的分子机制.
结论:
- 自然产品是开发神经退行性疾病新型治疗方法的宝贵资源.
- 了解它们的分子机制对于推进针对AD和PD的治疗策略至关重要.
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