SDHi杀菌剂:一种针对糖酸脱酶复合体的线粒毒农药的例子
Carolina Duarte Hospital1, Arnaud Tête1, Kloé Debizet1
1Université Paris Cité, INSERM UMR-S 1124, T3S, 45 rue des Saints-Pères, 75006 Paris.
Environment international
|October 1, 2023
概括
酸脱酶抑制剂 (SDHi) 杀菌剂可能会给农作物带来超越农作物的风险. 这些农药可以抑制包括人类在内的非标生物体中的酸脱酶 (SDH),通过非基因毒性机制可能导致毒性作用和癌症.
科学领域:
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
- 环境科学 环境科学
背景情况:
- 酸脱酶抑制剂 (SDHi) 是一种杀菌剂,向酸脱酶 (SDH),这对线粒体的能量产生至关重要.
- SDH在线粒体呼吸链和克雷布斯循环中至关重要;它在人类中的功能障碍与癌症等病理有关.
- 人类遗传的SDH缺陷会导致氧化应激,伪催和代谢重编程,类似于神经内分泌瘤中观察到的效应.
研究的目的:
- 审查SDHi在非目标生物中的毒性影响,并评估对农药风险评估的影响.
- 为了调查SDHi可能由于保存SDH结构而对人类产生毒性影响的假设.
- 检查动物研究中观察到的SDHi的非遗传毒性致癌机制.
主要方法:
- 对非目标物种SDHi毒性研究的文献综述.
- 对不同物种SDH结构保护的分析.
- 审查关于SDHi在动物中的致癌性的监管评估报告.
主要成果:
- SDH结构高度保存,允许SDHi在包括人类在内的非真菌物种中抑制SDH.
- SDHi在非目标生物体中表现出有毒作用,引发了对生态和人类健康的担忧.
- 动物研究表明,SDHi可以通过非遗传毒性机制诱导瘤,可能与SDH抑制有关.
结论:
- 由于它们对SDH的广泛抑制作用,SDHi杀菌剂可能对人类健康和环境构成风险.
- SDHi的非遗传毒性致癌潜力需要进一步调查,并突出了当前风险评估框架中的差距.
- 迫切需要重新评估对SDHi等线粒毒农药的监管评估策略.
更多相关视频
11:47Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
Published on: January 22, 2017
10.6K
08:57Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Published on: February 24, 2018
10.1K
相关概念视频
Electron Transport Chain: Complex I and II
14.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.3K
Fungal Phylum Basidiomycota
118
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
118
The Electron Transport Chain
16.9K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
16.9K
Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
