不故意的体重减轻反映在COPD门诊患者的一年临床结果更差
Søren Kveiborg Yde1, Sabina Mikkelsen2, Mia Solholt Godthaab Brath3
1Department of Clinical Medicine, Aalborg University, Sdr. Skovvej 15, 9000 Aalborg, Denmark.
Clinical nutrition (Edinburgh, Scotland)
|October 1, 2023
概括
慢性肺炎患者的无意减肥 (UWL) 显著增加住院时间,并恶化生活质量 (QoL). 根据国际COPD指南,建议与BMI一起定期对UWL进行查.
科学领域:
- 肺部医学 肺部医学
- 临床营养学 临床营养学
- 健康 结果 研究 研究 结果
背景情况:
- 在慢性阻塞性肺病 (COPD) 患者中,无意减肥 (UWL) 是常见的.
- 对UWL作为临床结果的独立预测因素的研究是有限的.
- 了解UWL的影响对于改善COPD患者管理至关重要.
研究的目的:
- 调查COPD门诊患者体质指数 (BMI),UWL和临床结果之间的关联.
- 评估UWL对住院,住院时间,恶化,死亡率和生活质量 (QoL) 的影响.
- 在评估后的六个月和一年内评估这些结果.
主要方法:
- 对200名COPD门诊患者进行的前性单中心队列研究.
- 通过电子期刊和问卷收集的基线数据 (UWL定义为3个月内5%的体重减轻).
- 六个月和一年的随访包括医学期刊,电话采访 (EQ-5D-5L,SARC-F) 和恶化的计数. 使用了后勤和考克斯回归分析.
主要成果:
- 187名患者完成了随访 (平均年龄69.2岁,43.9%的男性,BMI中位数为26.8公斤/米2).
- UWL的流行率为13.4%.
- UWL与住院时间>5天 (OR=2.94,p=0.021) 和更糟糕的QoL风险增加近三倍相关. 体重不足的患者患有更高的恶化风险 (OR=4.94,p=0.014). 没有观察到有意义的死亡率差异.
结论:
- 无意减肥 (UWL) 独立地预测了COPD患者更长的住院时间和更差的生活质量 (QoL).
- 除了BMI,还应考虑定期对UWL进行查,以符合国际COPD门诊指南.
- 这些发现支持积极的营养评估和干预COPD管理.
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