在患有急性缺血性中风或TIA的患者中尿体和中风复发
Liye Dai1, Anxin Wang2, Hongqiu Gu2
1Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
概括
阳性尿体增加了急性缺血性中风 (AIS) 或短暂缺血性发作 (TIA) 患者中复发性中风的风险. 这一发现突出了中风复发风险评估的潜在生物标志物.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 尿体在中风的急性阶段可以变化.
- 了解复发性中风的预测因素对于患者管理至关重要.
研究的目的:
- 调查尿体存在与复发性中风发生之间的关联.
- 分析患有急性缺血性中风 (AIS) 或短暂缺血性发作 (TIA) 的患者的这种关联.
主要方法:
- 利用了来自第三中国国家中风注册局 (CNSR-III) 的数据,其中包括14015名患有AIS或TIA的患者.
- 在1年的随访期间,对尿体进行了查,并对任何中风,缺血性中风或联合血管事件进行监测.
- 采用了Cox的比例危险模型来分析尿体和复发性中风之间的关联.
主要成果:
- 共有1335名 (9.53%) 参与者在一年内经历了复发性中风.
- 在调整了混因素后,阳性尿体与明显更高的中风复发风险有关 (HR, 1.43; 95% CI, 1.13-1.82).
- 这种关联在患有和没有糖尿病的患者中保持一致,没有观察到显著的相互作用.
结论:
- 尿液中体的存在是AIS或TIA患者中复发性中风的独立风险因素.
- 尿体检测可以作为一种有价值的工具,用于识别患有随后脑血管事件风险较高的患者.
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