蛋白质素化:抑制,识别和插入
Leonard Barasa1,2, Paul R Thompson1,2
1Program in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
概括
蛋白质素化,是一种由蛋白质氨酸减弱酶 (PAD) 酶的修饰,与疾病有关,并作为诊断标记物. 研究推进了PAD抑制剂和素蛋白鉴定,以了解疾病.
科学领域:
- 生物化学和分子生物学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 蛋白质素化是一种由蛋白质氨酸脱酶 (PAD) 酶催化后翻译性修饰 (PTM),将氨酸转化为氨酸.
- 这种PTM在基因表达,中性粒细胞外细胞陷形成和细胞亡中发挥作用,并与自身免疫性疾病,神经退行和癌症有关.
研究的目的:
- 审查开发蛋白质 arginine deiminase (PAD) 抑制剂的进展,包括泛PAD和异酶选择性.
- 讨论识别类蛋白质和特定位点的类蛋白内置的进展.
- 突出素蛋白的诊断和生物标志物潜力,特别是在类风湿性关节炎中.
主要方法:
- 关于PAD抑制剂和素化检测技术的当前文献的综述.
- 讨论由于质量变化最小而导致的素化残留物鉴定所面临的挑战.
- 在临床前和临床研究中探索PAD抑制剂的治疗疗效.
主要成果:
- PAD抑制剂在风湿性关节炎,狼,动脉样硬化和性结肠炎的临床前模型中显示出显著的疗效.
- 反素蛋白抗体是风湿性关节炎早期诊断的有价值的标志物.
- 在开发向PAD抑制剂和识别素蛋白的方法方面取得了进展.
结论:
- 蛋白质素化是一个关键的PTM,对健康和疾病有重大影响.
- 向PAD酶为各种自身免疫和炎症性疾病提供了一个有前途的治疗策略.
- 改进的素蛋白鉴定方法对于推进诊断和了解疾病机制至关重要.
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