的流行病学Mycobacterium的
Cesar Cristancho-Rojas1, Cara D Varley2, Sofia Chapela Lara1
1School of Public Health, Oregon Health & Science University-Portland State University, Portland, OR, USA.
概括
非结核菌 (NTM),特别是 Mycobacterium abscessus,正在越来越多地引起疾病. 了解它们的流行病学对于临床实践和对这些抗生素耐药病原体的未来研究至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 非结核菌 (NTM) 在环境中无处不在,导致人类频繁暴露.
- 菌根是一种重要的机会性病原体,以其抗生素耐药性和与肺部疾病日益相关而闻名.
- Mycobacterium abscessus complex (MABC) 的分类已经通过分子技术进行了细化,揭示了它形成生物膜并在水系统中持久的能力.
研究的目的:
- 审查和描述Mycobacterium的流行病学.
- 专注于M.瘤感染的临床方面.
- 综合有关MABC发生和疾病模式的当前知识.
主要方法:
- 从2010年到现在的PubMed和知识网络的文献搜索.
- 使用的关键词是:"Mycobacterium abscessus"",非结核菌"和"流行病学".
- 关于NTM和M.疹感染/疾病发生的原始报告的优先级.
主要成果:
- 流行病学证据表明,MABC感染和疾病在过去十年中呈上升趋势.
- 在患有支气管病症等潜在肺部疾病的个体中,MABC肺部疾病很普遍.
- 传播性MABC疾病与免疫抑制有关,而皮肤/软组织感染与程序有关.
结论:
- 疾病负担的准确评估受到可变报告,偏见和不同的医疗实践的阻碍.
- 需要对环境因素,感染途径和MABC肺病机制进行进一步的研究.
- 本综述增强了对MABC流行病学的理解,以指导临床实践和未来的调查.
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