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开发天然杀手组2D受体 (NKG2D) 的小分子抑制剂

Jocelyn Wang1, Kohki M Nakafuku1, Jeannie Ziff1

  • 1Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States.

Bioorganic & medicinal chemistry letters
|October 1, 2023
PubMed
概括

研究人员开发了向NKG2D/NKG2DL通路的小分子抑制剂,这在自身免疫性疾病中至关重要. 这些强大的化合物通过阻断NKG2D及其配体之间的相互作用,为免疫调节提供了有希望的途径.

关键词:
有一个神秘的口袋.免疫受体是一种免疫受体.在NKG2D中,它是NKG2D.蛋白质蛋白质相互作用基于结构的药物设计.

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