数字双胞胎支持的个性化营养改善了2型糖尿病中代谢功能障碍相关的脂肪肝疾病:为期一年的随机对照研究结果
Shashank Joshi1, Paramesh Shamanna2, Mala Dharmalingam3
1Department of Diabetology and Endocrinology, Lilavati Hospital and Research center, Mumbai, India.
数字双胞胎技术个性化营养,活动和睡眠显著改善了2型糖尿病 (T2D) 和代谢功能障碍相关的脂肪肝疾病 (MAFLD) 标志物. 这种方法使得T2D患者的血糖控制和肝脂肪减少得到了实质性的改善.
科学领域:
- 代谢性疾病研究研究.
- 数字健康技术数字健康技术
- 个性化医疗是个性化的医疗.
背景情况:
- 餐后高血糖会导致胰岛素抵抗,炎症和与代谢功能障碍相关的脂肪肝疾病 (MAFLD).
- 数字双胞胎 (DT) 技术为个性化营养,活动和睡眠干预提供了一条途径,以管理2型糖尿病 (T2D) 和MAFLD.
研究的目的:
- 评估DT启用个性化干预措施对T2D患者血糖状况的影响.
- 评估DT引导的生活方式改变对MAFLD代用标记物和肝脂肪含量的影响 (MRI-PDFF).
主要方法:
- 一个开放的随机试验,比较DT干预 (n=319) 与标准护理 (SC).
- DT组接受了人工智能驱动的个性化饮食计划,以最小的食后血糖反应为目标.
- 主要终点包括血红蛋白A1c (HbA1c) 的变化和药物减少;次要终点包括MAFLD标志物和通过MRI的肝脂肪.
主要成果:
- DT组显示出明显更大的HbA1c降低 (-2.9%vs-0.3%) 和1年后72.7%的T2D缓解率.
- 与SC相比,在DT组中观察到非酒精性脂肪性肝病 (NAFLD) 肝脂肪和纤维化得分的显著改善.
- MRI-PDFF证实了DT组肝脏脂肪含量的显著降低.
结论:
- 启用DT的个性化治疗有效改善T2D患者的高血糖症.
- 这种方法在改善MAFLD的替代标记物和减少肝脏脂肪方面表现出显著的有效性.
- 对于T2D和MAFLD的个性化管理,DT技术具有前景.
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