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Updated: Jul 15, 2025

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FGFR1的D647N突变诱导了连接体独立的受体激活

Mattia Domenichini1, Cosetta Ravelli1, Michela Corsini1

  • 1Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.

Biochimica et biophysica acta. General subjects
|October 1, 2023
PubMed
概括

纤维细胞生长因子受体1 (FGFR1) 中的D647N突变驱动癌症的攻击性,并增强对抑制剂埃尔达菲提尼布的敏感性. 这种激活突变可能预测癌症患者对埃尔达菲提尼布治疗的积极反应.

关键词:
这就是ATPATPATP ATP.一个FGFR1.瘤原性突变是一种致癌突变.铁氨酸激酶抑制剂 铁氨酸激酶抑制剂

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