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通过鼻-大脑通路传递的刺激响应纳米粒子通过广泛清理ROS来缓解类似抑郁症的行为

Lin Liu¹, Min Liu¹, Jingya Xiu¹

¹College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

Acta biomaterialia

|October 1, 2023

概括

这项研究开发了新的纳米粒子,可以将抗氧化剂直接输送到大脑,有效地减少氧化应激,并通过绕过血脑屏障来缓解抑郁症症状.

科学领域:

神经科学是一个神经科学.
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

抑郁症是一种常见的精神障碍,严重影响健康.
氧化应激 (OS) 和神经退行是抑郁症发病的关键因素.
血脑屏障 (BBB) 阻碍了抑郁症治疗中有效的脑药物输送.

研究的目的:

设计ROS清理纳米粒子 (NP) 通过鼻-大脑通路直接输送到大脑.
将ROS清理与抗抑郁药物输送相结合,以加强抑郁症治疗.
为了克服BBB的局限性,改善了抑郁症的抗氧化疗法.

主要方法:

合成的六氨酸 (R6) 改性ROS响应的德克斯 (DEX) 衍生物.
装载纳米粒子 (NP) 与奥兰扎 (Olz) 和H2供体氨基 (AB),以创建Olz/RDPA NP.
在以波洛克萨默为基础的热敏水凝中分散的NP用于鼻腔输送.

主要成果:

奥尔兹/RDPANP通过鼻-大脑通路有效地传递到大脑.
水凝系统成功地证明了ROS耗尽和抑制5-HT功能障碍.
在体内研究表明,缓解了类似抑郁症的行为.

结论:

热反应性水凝中的Olz/RDPANP为抑郁症治疗提供了一个有前途的策略.
有针对性的ROS清理和通过鼻-大脑通道改善大脑输送是有效的.
这种纳米治疗方法通过向氧化应激,为治疗抑郁症开辟了新的途径.

关键词:

抑郁症抑郁症抑郁症水凝是一种水凝.气气是一种气.在ROS清理垃圾.对ROS有反应的纳米粒子.

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