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功能单心室与完全异常的肺静脉连接的当代结果

Tracy R Geoffrion¹, Danielle I Aronowitz², Colleen Mangeot³

¹Division of Pediatric Cardiothoracic Surgery, Children's Wisconsin, Milwaukee, Wis.

The Journal of thoracic and cardiovascular surgery

|October 1, 2023

概括

单心室解剖与完全异常的肺静脉连接的生存率已经平稳. 缺血性左心综合征和肺静脉阻塞仍然是这些患者死亡的关键风险因素.

科学领域:

儿童心脏病学儿童心脏病学
遗传性心脏病研究遗传性心脏病研究
手术结果分析手术结果分析

背景情况:

功能单心室解剖学和全异常肺静脉连接 (TAPVC) 呈现复杂的先天性心脏缺陷.
之前的报道表明,2004年该患者群体的早期生存率有所改善.
当代结果需要评估,以评估长期生存趋势.

研究的目的:

为了确定单心室解剖和TAPVC患者的生存结果是否在当代时代有所改善.
分析不同时期的生存趋势.
为了确定与这一群体的死亡率相关的风险因素.

主要方法:

在1984年至2021年期间入院的190名单心室解剖和TAPVC患者的单中心回顾性综述.
患者被分为三个阶段:1984-1992,1993-2007年和2008-2021年.
考克斯的比例危险模型被用来评估死亡风险.

主要成果:

总体生存率从第1时代改善到第2和第3时代 (P < .001),但自2000年代初以来稳定下来.
十年生存率为15% (第一时代),51% (第二时代) 和54% (第三时代).
缺血性左心综合征 (HR, 1.60) 和肺静脉阻塞 (HR, 1.80) 是死亡的重要风险因素.

结论:

用TAPVC进行单心室解剖的存活率已经稳定,即使在最近的时代,10年存活率也低于60%.
缺血性左心综合征和肺静脉阻塞是影响死亡率的关键风险因素.
需要进一步的研究来阐明导致持续死亡的病理生理机制.

关键词:

在 CHD 中,您可以使用 CHD.这里是Fontan Fontan.格伦格伦格伦格伦格伦格伦格伦格伦格伦格伦诺伍德 (Norwood) 诺伍德 (Norwood) 是一个位于美国的城市.在TAPVC上,我们可以看到.这是先天的,先天的.结果就是结果.一个单心室单心室.

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