在法国E3N队列内的一项嵌套病例控制研究中,空气中累积的二氧化暴露与非霍奇金淋巴瘤风险之间的关联
Elizabeth Gaspard1, Pauline Frenoy1, Delphine Praud2
1Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805 Villejuif, France.
The Science of the total environment
|October 1, 2023
概括
这项研究发现,较高的累积空气中二氧化暴露与女性非霍奇金淋巴瘤 (NHL) 风险增加有关. 这种联系对于慢性淋巴细胞白血病 (CLL) 和小淋巴细胞淋巴瘤 (SLL) 亚型特别强烈.
科学领域:
- 环境流行病学环境流行病学
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 二氧化物是持久的,生物累积的环境污染物,具有已知的致癌性质.
- 以前的研究表明,二氧化碳暴露与癌症风险增加之间存在潜在联系.
- 这项研究是首次调查空气中的二氧化暴露和非霍奇金淋巴瘤 (NHL) 风险.
研究的目的:
- 评估空气中累积的二氧化暴露与发展NHL的风险之间的关联.
- 检查特定的NHL亚型与二氧化暴露有关.
主要方法:
- 在法国E3N队列 (98,995名女性) 内的嵌套病例控制研究.
- 使用基于GIS的指数 (1990-2008) 评估了个人层面的累积空气中的二氧化暴露.
- 多变量条件逻辑回归模型用于计算赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 在累积的二氧化碳暴露和NHL风险之间观察到显著的正相关性 (或每次SD增加1.2次).
- 慢性淋巴细胞白血病 (CLL) 和小淋巴细胞淋巴瘤 (SLL) 亚型与二氧化暴露显著相关 (OR 1.6).
结论:
- 累积的空气中二氧化暴露与女性NHL风险增加有显著的关联.
- 淋巴结核病的CLL和SLL亚型与更高的二氧化暴露有关.
- 这些发现支持了减少空气中的二氧化暴露的公共卫生努力.
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