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小动物DXA仪器对比和验证.

Jennifer C Coulombe1, David E Maridas2, Jarred L Chow3

  • 1Center for Advanced Orthopedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.

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概括

新的动物双能X射线吸收计 (DXA) 装置,InAlyzer和 iNSiGHT,为骨和身体组成分析提供了出色的精度. 在骨矿物质含量方面,InAlyzer显示出更高的准确性,使其成为肌肉骨研究的首选.

关键词:
在 BMC BMC BMC 的位置上.这就是为什么B.M.D. BMD.身体组成 身体组成DXA DXA 是一个脂肪质量 脂肪质量在Alyzer中瘦质量 瘦质量 瘦质量鼠模型的模型.这是NMR的NMR.这就是PIXImus.验证 验证 验证 验证在iNSight的视野中.微型CTCT是什么意思

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科学领域:

  • 生物医学工程 生物医学工程
  • 骨科 骨科是指骨科的学科.
  • 动物模型 动物模型

背景情况:

  • 外围双能X射线吸收度 (DXA) 对于动物骨和身体成分分析至关重要.
  • 新的DXA设备 (InAlyzer, iNSiGHT) 已经出现,需要进行性能评估.
  • 已建立的PIXImus设备性能作为一个基准.

研究的目的:

  • 为了比较InAlyzer和 iNSiGHT DXA设备与PIXImus系统的准确性和精度.
  • 评估新的DXA设备对动物骨矿物质含量,骨矿物质密度和身体成分测量的性能.
  • 通过核磁共振 (NMR) 验证DXA的身体组成,通过微计算断层扫描 (microCT) 验证骨矿物质含量.

主要方法:

  • 18只雄性C57Bl/6J小鼠 (8,14,24周大) 使用InAlyzer, iNSiGHT和PIXImus DXA设备进行了扫描.
  • 测量了全身骨矿物质含量 (BMC),骨矿物质密度 (BMD),瘦肉质量和脂肪质量.
  • Femur BMC 与microCT进行了比较,身体组成与NMR进行了比较.

主要成果:

  • 在Alyzer和iNSiGHT中,全身BMD与PIXImus的相关性很强 (R2=0.83,0.82),但比PIXImus高25%左右.
  • 在Alyzer中,全身BMC (R2=0.86) 和股骨BMC与microCT有很强的关联,而iNSiGHT显示的相关性很弱.
  • 这两种设备都表现出极好的精度 (0.39-3.2%) 和脂肪质量 (R2=0.91-0.97) 和瘦肉质量 (R2=0.81-0.76) 的强烈相关性.

结论:

  • InAlyzer 和 iNSiGHT 是已停产的 PIXImus 系统的满意替代品,提供更快的扫描时间和出色的精度.
  • 在专注于肌肉骨变化的研究中,因其在骨和身体成分测量方面的卓越准确性,InAlyzer可能是更好.
  • 这两种设备都提供了可靠的身体组成数据,InAlyzer为骨相关研究提供了更高的准确性.