在青光眼中神经血管功能障碍
Luis Alarcon-Martinez1, Yukihiro Shiga2, Deborah Villafranca-Baughman2
1Department of Neuroscience, Université de Montréal, PO Box 6128, Station centre-ville, Montreal, QC, Canada; Neuroscience Division, Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montreal, QC, Canada; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
Progress in retinal and eye research
|October 1, 2023
概括
玻璃眼会损害视网膜质细胞,原因是血液流量调节受损. 这篇评论探讨了神经血管单元.
科学领域:
- 眼科和神经科学 眼科和神经科学
- 血管生物学 血管生物学
- 细胞生物学 细胞生物学
背景情况:
- 视网膜质细胞需要大量的氧气和营养,使血流调节至关重要.
- 玻璃眼与血管缺陷有关,包括受损的自身调节和神经血管合.
- 神经血管单元,包括各种细胞类型,编排视网膜血流和功能.
研究的目的:
- 审查神经血管单元在调节视网膜血流中的作用.
- 为了检查玻璃眼压力如何影响神经血管相互作用.
- 突出介质细胞和道纳米管在视网膜血管调节中的功能.
主要方法:
- 文献综述专注于格洛科马的神经血管单元.
- 对神经血管相互作用的细胞和分子机制的分析.
- 在视网膜血管系统中讨论细胞细胞功能和道化纳米管.
主要成果:
- 神经血管单元的组成部分对于维持视网膜平衡至关重要.
- 细胞在神经血管合中发挥着重要作用,特别是通过道化纳米管.
- 功能障碍的神经血管单元有助于眼病理.
结论:
- 了解神经血管单元功能障碍是开发青光眼治疗的关键.
- 针对皮细胞和道纳米管提供了血管保护和再生的潜力.
- 恢复神经血管功能可能会改善青光眼患者的治疗结果.
相关概念视频
Glaucoma: Overview
614
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
614
Open Angle Glaucoma: Treatment
474
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
474
Angle Closure Glaucoma: Treatment
555
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
555
Photoreceptors and Visual Pathways
6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K


