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相关概念视频

Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

28.0K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
28.0K
Gene Families01:57

Gene Families

8.9K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.9K
Phylogeny01:23

Phylogeny

44.3K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
44.3K
Phylogenetic Trees03:21

Phylogenetic Trees

45.4K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.4K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.8K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.8K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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相关实验视频

Updated: Jul 15, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

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对生物实体的超标层次知识图嵌入式.

Nan Li1, Zhihao Yang1, Yumeng Yang1

  • 1College of Computer Science and Technology, Dalian University of Technology, Dalian, China.

Journal of biomedical informatics
|October 1, 2023
PubMed
概括

HEM是一种过度的等级知识图嵌入模型,通过保留在欧几里德嵌入中丢失的等级信息来改善生物实体的表示. 这增强了对蛋白质-蛋白质相互作用和基因-疾病关联的预测.

科学领域:

  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.
  • 机器学习 机器学习

背景情况:

  • 预测生物关系对于生物医学研究至关重要.
  • 欧几里德空间中现有的嵌入方法在很大的图形结构数据中难以保留层次信息.
  • 这种限制阻碍了对生物实体和关系的准确语义表示.

研究的目的:

  • 提出HEM,一个夸张的等级知识图嵌入模型.
  • 为生物实体生成准确的矢量表示.
  • 为了有效地捕获潜在的等级信息,以改善生物预测.

主要方法:

  • 开发了HEM,这是一个利用超标空间 (Poincaré球) 嵌入知识图的新型模型.
  • 编码的生物实体和关系在超标几何体内,以利用其负曲率.
  • 应用HEM用于蛋白质-蛋白质相互作用和基因-疾病关联预测任务.

主要成果:

  • HEM成功地捕获了潜在的层次信息,超过了欧几里德嵌入方法.
  • 该模型在预测蛋白质-蛋白质相互作用和基因-疾病关联方面取得了卓越的准确性.
  • 与欧几里德的方法相比,HEM在低维表示中保存了丰富的生物信息.
关键词:
超标知识图嵌入式嵌入式知识图表知识图表蛋白蛋白相互作用预测的预测

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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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结论:

  • 超标知识图嵌入提供了一个强大的方法来建模生物数据.
  • 在生物关系预测方面,HEM在准确性和信息保存方面取得了显著的改进.
  • 拟议的方法提供了一个有价值的工具,通过增强的生物实体代表来推进生物医学研究.