生物制药行业排放的VOC:来源概况,健康风险和二次污染
1State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
生物制药制造业释放出大量挥发性有机化合物 (VOC),造成环境和健康风险. 这项研究确定了主要的VOC和排放源,并建议针对优先污染物进行有针对性的控制,以减轻风险.
科学领域:
- 环境化学环境化学
- 工业生态学 工业生态学
- 职业健康 职业健康 职业健康
背景情况:
- 生物制药制造业是挥发性有机化合物 (VOC) 排放的重要来源.
- 这些排放引发了环境问题,并可能导致社会冲突.
- 了解基于工艺的VOC排放对于风险评估和缓解至关重要.
研究的目的:
- 调查和描述生物制药企业基于工艺的VOC排放.
- 确定优先排放的VOC污染物及其排放来源.
- 评估这些排放的大气扩散,健康风险和二次污染潜力.
主要方法:
- 在现场调查三家生物制药工厂的VOC排放情况.
- 检测到的VOC被分为四类:碳化合物,芳香碳化合物,含氧化合物和含化合物.
- 应用模糊的综合评估系统和高斯羽流扩散模型进行风险评估.
主要成果:
- 确定了26种挥发性有机化合物,其中类是占主导地位的类别 (44.13%-77.85%).
- 铁氨酸酸的发酵和提取单位是主要的排放来源.
- 优先污染物包括二甲基他,乙乙酸,二甲基胺,烯基醇甲基乙烯 (PGME) 和,已确定风向下2公里的健康风险.
结论:
- 生物制药产品的VOC排放具有很高的大气扩散性,并带来非致癌和致癌风险.
- 特定的化合物,如N-甲基-2-pyrrolidone,二甲基 heptanone,和PGME需要控制,以减少臭氧形成的潜力.
- 控制和二对于最大限度地减少二次有机气溶 (SOA) 生产至关重要.
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