自发性细菌周周炎的临床特征,微生物频谱和抗生素敏感性模式在肝硬化患者中
Xin Zhang1, Xiao-Xi Li2, Jin-Wen Song1
1Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, 100039, Beijing, China.
概括
耐多药细菌在自发性细菌性腹膜炎 (SBP) 中很常见. 广泛耐药性感染,高MELD得分和中性粒细胞计数预测SBP患者的住院死亡率,需要密集护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 在全球范围内,自发性细菌性腹膜炎 (SBP) 呈现出不断演变的微生物耐药性模式.
- 了解预测SBP患者住院死亡率的因素至关重要.
研究的目的:
- 分析SBP中的微生物频谱和抗菌素耐药性.
- 确定SBP患者住院死亡率的预测因素.
主要方法:
- 对377名SBP患者和794名bacterascites患者的分析.
- 评估微生物频谱,抗菌素耐药性和实验室发现.
主要成果:
- 最常见的病原体是大肠杆菌,葡萄球菌表皮菌和菌菌.
- 耐多药性 (MDR) 细菌构成了近一半的分离物.
- 广泛耐药性 (XDR) 感染,高MELD得分和中性粒细胞计数独立预测死亡率.
结论:
- 近50%的SBP细菌分离物是MDR,产生ESBL和耐卡巴胺菌株的比例令人担忧.
- 在SBP中,XDR,较高的MELD和中性粒细胞数量是死亡率的独立预测因素.
- 建议SBP患有这些危险因素的患者进行密切护理.
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