在患有动脉样硬化脆弱斑块和稳定斑块的患者之间,外周循环微RNA-146a的差异表达
Yenwen Song1, Lei Zhang1, Ye Huang1
1Department of Emergency, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine.
International heart journal
|October 1, 2023
概括
循环中的microRNA-146a (miR-146a) 水平在患有易受动脉样硬化斑块的患者中明显高于稳定的斑块. 这一发现表明miR-146a可能作为斑块脆弱性的潜在生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 动脉硬性斑块破裂是心血管疾病的主要原因之一.
- 微RNA-146a (miR-146a) 多态性与斑块脆弱性有关.
- 循环中的miR-146a水平在区分稳定和脆弱斑块中的作用尚不清楚.
研究的目的:
- 为了研究稳定和脆弱的动脉样硬化斑块之间的循环miR-146a的差异表达.
- 探索miR-146a作为斑块脆弱性的生物标记物的潜力.
- 分析涉及miR-146a.的潜在分子机制.
主要方法:
- 系统审查和对已发表的研究进行元分析,截至2022年11月.
- 包括报告在稳定患者和脆弱斑块患者中循环miR-146a水平的研究.
- 使用修改后的纽卡斯尔-太华尺度和标准化平均差异 (SMD) 的元分析进行质量评估.
主要成果:
- 分析了8项涉及978名患者的研究.
- 在易受损伤的斑块组中,循环中的miR-146a水平显著更高 (SMD: 1.91,P < 0.01).
- 小组分析和敏感性分析证实了这些发现的可靠性.
结论:
- 与有稳定斑块的患者相比,患有脆弱动脉样硬化斑块的患者表现出循环中的miR-146a水平升高.
- miR-146a可能是识别脆弱斑块的潜在生物标志物.
- 需要进一步的高质量研究来验证这些发现并阐明潜在的机制,可能涉及ACTN4,SARM1和ULK2调节.
相关概念视频
Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Peripheral Artery Disease I: Introduction
9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9
Inflammation
53.8K
Overview
53.8K


