白内障手术和慢性病:一个基于医院的前性队列研究
Minako Wakasugi1, Akio Yokoseki1, Masakazu Wada2
1Department of Inter-Organ Communication Research, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Internal medicine (Tokyo, Japan)
|October 1, 2023
概括
透析依赖慢性病 (CKD) 的患者患白内障手术的风险更高. 然而,当考虑与死亡竞争的风险时,这种增加的风险并不显著.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
背景情况:
- 白内障和慢性病 (CKD) 是与年龄相关的疾病,具有糖尿病和高血压等风险因素.
- 评估CKD阶段与白内障手术风险之间的联系对于了解疾病进展和患者的结果至关重要.
研究的目的:
- 评估非透析依赖的CKD和透析依赖的CKD患者与没有CKD的患者之间发生白内障手术的风险.
- 在分析白内障手术发病率时,要考虑到死亡的竞争风险.
主要方法:
- 分析了1839名来自萨多全身健康项目 (PROST) 的患者队列.
- 参与者被分为非CKD,非透析依赖的CKD和透析依赖的CKD组.
- 使用竞争性风险分析来评估CKD和白内障手术之间的关联,将死亡视为竞争性事件.
主要成果:
- 白内障手术的累积发病率在依赖透析的CKD组中最高.
- 透析依赖的CKD与较高的白内障手术风险相关 (HR 2.48) 在考虑竞争风险之前.
- 在调整了相应的死亡风险后,透析依赖性CKD和白内障手术之间的关联不再具有统计学意义 (SHR 1.67).
结论:
- 透析依赖的CKD患者面临着接受白内障手术的高风险.
- 在透析依赖的CKD患者中,白内障手术的风险增加在考虑死亡的竞争风险时会减弱.
- 可能需要进一步的研究来澄清晚期CKD和白内障发展之间的关系.
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