在与细胞外电场的乳头网状神经元中,低值电流调节的树突Ca2+响应的状态依赖调节
Yaqin Fan1, Xile Wei1, Meili Lu2
1Tianjin Key Laboratory of Process Measurement and Control, School of Electrical and Information Engineering, Tianjin University, Tianjin, China.
Scientific reports
|October 1, 2023
概括
在体网状核 (TRN) 中,来自深度大脑刺激 (DBS) 的电场 (EF) 调节神经元发射模式. 这些EFs影响反应,影响治疗机制.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 计算神经科学是一种神经科学.
背景情况:
- 胸膜网状核 (TRN) 的深度大脑刺激 (DBS) 是对抗药性的有希望的治疗方法.
- 来自DBS的电场 (EF) 影响TRN神经元活动的精确生物物理机制仍然不完全理解.
研究的目的:
- 研究EF如何调节TRN神经元中低值树突 (dCa) 反应.
- 阐明EF调制的dCa反应对TRN细胞整体输入输出关系的贡献.
主要方法:
- 对受不同电场参数影响的TRN神经元进行计算建模.
- 分析不同刺激条件下的神经元发射模式,动作潜能 (AP) 生成和树突动力学.
- 研究神经元内在特性 (如轴阻) 对EF效应的影响.
主要成果:
- EFs表现出神经元发射模式的状态依赖调制,影响尖峰时间和单个AP和突发发射之间的过渡.
- EFs显著影响dCa反应,特别是在超极化状态中,改变突发放电模式,并可能诱导向单个AP过渡.
- 对刺激值的EF影响与EF调节的dCa反应密切相关,刺激和EF应用之间的时间差异产生了不同的结果.
结论:
- 神经元内在的特性,如轴电阻,极大地影响EFs如何调节树突反应和整体神经元活动.
- 即使在轴阻高的神经元中,EFs也可以诱导依赖状态的dCa反应,模仿在较低阻力条件下观察到的效应.
- 了解这些生物物理相互作用为治疗的DBS治疗机制提供了关键的见解.
相关概念视频
01:19The Role of Ion Channels in Neuronal Computation
3.2K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.2K
01:27Feedback Regulation of Calcium Concentration
3.4K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.4K