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MMiKG:一个基于知识图的平台,用于挖掘微生物群与精神疾病相互作用的途径

Haoran Sun¹, Zhaoqi Song², Qiuming Chen¹

¹School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China.

Briefings in bioinformatics

|October 2, 2023

概括

这项研究绘制了微生物群-肠-大脑轴的地图,详细介绍了肠道微生物与大脑之间的相互作用. 开发的知识图,MMiKG,有助于理解精神障碍和治疗发展.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
计算生物学计算生物学

背景情况:

微生物群-肠道-大脑轴描述了肠道微生物群和中枢神经系统之间的双向通信.
关于这一轴的现有知识是分散的,阻碍了全面的理解和人工智能开发.
这个轴通过复杂的相互作用影响宿主的情绪,认知和行为.

研究的目的:

巩固关于微生物群-肠道-大脑轴的碎片化知识.
开发一个结构化知识图 (MMiKG) 以可视化和分析这些交互.
促进对精神障碍病原的更深入的理解,并确定新的治疗策略.

主要方法:

进行了广泛的文献审查,以对微生物群-肠-大脑轴的信息进行整理.
开发微生物群-肠-大脑轴知识图 (MMiKG).
使用GraphXR和Neo4j进行可视化和数据管理.

主要成果:

创建MMiKG,一个综合多元数据资源的综合知识图.
MMiKG 能够可视化肠道微生物群与中枢神经系统之间的联系.
该平台有助于探索与心理健康相关的潜在联系.

结论:

MMiKG为了解微生物群-肠-大脑轴提供了一个统一的平台.
知识图有助于理解精神障碍机制.
MMiKG为推进该领域的治疗干预和研究提供了新的见解.

关键词:

在MGB轴上设置MGB轴.我们的肠道微生物群.这是一种中间产品.知识图表知识图表精神疾病是一种精神疾病.

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