β-葡萄糖在儿童中的抗感染作用
Katarzyna Wzorek-Łyczko1, Weronika Woźniak1, Anna Piwowarczyk1
1The Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Poland.
概括
贝塔葡萄糖,天然的免疫调节化合物,在减少儿童呼吸道感染方面表现有前途. 这些化合物在儿科研究中表现出良好的耐受性和良好的安全性.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 儿科 儿科 儿科
背景情况:
- β-葡萄糖是一种天然的生物活性多糖,具有抗微生物和免疫调节性质.
- 它们具有较低的毒性风险,使得它们对治疗应用具有吸引力.
研究的目的:
- 审查当前关于贝塔葡萄糖在儿科群体中的抗感染性质的知识.
- 评估贝塔葡萄糖对儿科感染的疗效和安全性.
主要方法:
- 根据PRISMA扩展范围审查检查清单进行范围审查.
- 在PubMed,Embase和Cochrane数据库进行系统的文献搜索,截至2021年5月.
- 包括12项研究,包括随机对照试验和干预前比较.
主要成果:
- 在12项研究中,有10项表明β-葡萄糖有效降低了儿童呼吸道感染的发生率或减轻了儿童的症状.
- 使用了各种β-葡萄糖的制剂和剂量,包括多和面包酵母β-葡萄糖.
- 十项研究报告了儿童参与者对β-葡萄糖干预措施的良好耐受性和安全性.
结论:
- 由于其良好的耐受性和安全性,β-葡萄糖具有有利的益处风险比.
- 建议进一步进行高质量的研究,以监测小儿群体中β-葡萄糖的疗效和安全性.
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