铁和对前列腺癌患者辐射敏感性的影响与对照对照相比
Varinderpal S Dhillon1, Permal Deo1, Michael Fenech1,2
1Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, 5000 Adelaide, Australia.
Mutagenesis
|October 2, 2023
概括
前列腺癌 (PC) 患者的高铁和水平增加了放射治疗导致的DNA损伤. 这表明基于营养的策略可以将接受放射治疗的PC患者的副作用降到最低.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 营养科学 营养科学
背景情况:
- 摄入大量红肉和乳制品可能会增加血铁和,这是已知的前列腺癌 (PC) 风险因素.
- 关于铁和对PC患者辐射敏感性的影响的研究有限.
研究的目的:
- 调查高血铁和水平是否会增加PC患者的基线或辐射诱导的DNA损伤,与健康个体相比.
- 测试这样的假设:铁和的含量增加会提高PC患者的DNA损伤敏感度.
主要方法:
- 这项研究涉及106名PC患者和132名健康对照.
- 细胞动力阻断微核 (CBMN) 试验用于测量淋巴细胞中的DNA损伤标记物 (微核,核等质桥梁,核芽).
- 血中铁和的度用诱导合的血原子发射光谱学量化.
主要成果:
- 与对照组相比,高血铁的PC患者显示辐射诱导的微核,核等离子体桥梁和核芽显著更高.
- 血高的PC患者表现出显著增加的辐射诱导的微核和核芽.
- 在PC患者中,铁和水平升高与辐射诱导核芽的显著增加有关.
结论:
- 高血铁和水平提高了前列腺癌患者接受放射治疗的DNA损伤敏感性.
- 研究结果表明,需要基于营养的策略来缓解PC患者正常组织中辐射诱导的DNA损伤.
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