肠道微生物群在小儿食品蛋白质诱导肠球炎综合征中受到改变
Esther Caparrós1, María Carmen Cenit2,3, Javier Muriel1
1Clinical Medicine Department, University Miguel Hernández, San Juan de Alicante, Alicante, Spain.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
患有食物蛋白诱导肠道炎综合征 (FPIES) 的儿童表现出明显的肠道微生物组成. 这一发现表明FPIES的潜在新诊断和管理策略,非IgE介导的食物过敏症.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 食物蛋白诱导肠道炎综合征 (FPIES) 是一种非IgE介导的胃肠过敏症,主要影响儿童.
- FPIES的确切病原性仍然不清楚,对诊断生物标志物的理解有限.
- 新出现的证据表明肠道微生物群在FPIES发展中的潜在作用.
研究的目的:
- 研究和比较被诊断患有FPIES的儿童的肠道微生物群组成与年龄和性别匹配的健康对照组.
- 在儿科群体中识别与FPIES相关的潜在微生物特征.
主要方法:
- 17名患有FPIES和12名健康对照儿童的便样本使用16S核糖体RNA基因测序 (V4-V5区域) 进行了分析.
- 收集了社会人口统计,临床和饮食数据,并在病例和对照组之间进行了比较.
- 使用非参数线性差异分析来分析肠道微生物群数据.
主要成果:
- 患有FPIES的患者表现出显著更高比例的Lachnospiraceae spp. 与对照组相比 (P < .0286).与对照组相比 (P < .0286).
- 相反,FPIES患者的Ruminococcaceae spp.的比例较低. (P <.0066), 乳酸菌科 spp. 的种类. (P < .0075),以及莱科诺斯托卡ceae spp. 的种类. (P <.0173) 的情况.
- 在65%的FPIES病例中,鱼被确定为主要的过敏原.
结论:
- 该研究在患有FPIES的儿童中发现了一种明显的肠道微生物特征.
- 这些发现表明,肠道微生物群的改变可能成为FPIES诊断和管理的潜在生物标志物.
- 需要进一步的大规模研究来验证这些初步结果.
关键词:
在FPIES的FPIES.拉克诺斯皮拉属植物 (Lachnospiraceae) 是一个乳酸菌家族中的乳酸菌.这种植物属于Leuconostocaceae.鲁米诺可可科科科 (Ruminococcaceae) 是一个植物.我们的肠道微生物群.微生物组是一个微生物组.非IgE介导的食物过敏症更多相关视频
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